Frequently Asked Questions

When it comes to your health, it’s normal to have a lot of questions.

Whether you’ve got questions about when and where Nexium® 24HR will be available to purchase, or how Nexium® 24HR works and should be taken, or even just the difference between Nexium® 24HR heartburn protection and prescription NEXIUM®, continue reading below.

Always use Nexium® 24HR as directed. If you have questions about using Nexium® 24HR with other medications you should ask your physician or pharmacist.

Nexium 24HR FAQs

Identifying Heartburn

Heartburn is an uncomfortable burning sensation in your chest or throat. It occurs when stomach acid rises up out of the stomach and irritates the esophagus.

Frequent heartburn is heartburn that occurs more than twice a week.

Heartburn is an uncomfortable burning sensation in your chest or throat, due to stomach acid that rises out of the stomach and into the esophagus. The pain can range from discomfort, to intense.

Heartburn is caused by stomach acid that rises up out of the stomach, goes through the lower esophageal sphincter (LES) and then up into the esophagus.

The acid rising up can be triggered by certain foods in your diet, such as citrus fruits, whole milk, tomato sauces or foods that are fatty or spicy. It can also be triggered by pressure on the stomach caused by weight gain or right fitting clothes.

Acid reflux is the backward flow of stomach acid into the esophagus At the entrance to the top of your stomach is a valve, called the lower esophageal sphincter (LES). Acid reflux occurs when stomach acid rises out of the stomach, travels past the LES, and into the esophagus, which can cause a burning sensation.

About Nexium® 24HR

Nexium® 24HR is an OTC medication indicated for the treatment of frequent heartburn (two or more days a week) in adults (18 years and older). The active ingredient in Nexium® 24HR is esomeprazole 20 mg.

In clinical trials, Nexium® 24HR has been shown to treat frequent heartburn for up to 24 hours when taken once each morning before eating for 14 consecutive days.

Nexium® 24HR should be taken only as directed, unless otherwise determined by a healthcare professional.

The formulations of the 20mg OTC capsules (Nexium® 24HR) and the prescription 20mg capsules (NEXIUM®) contain the same active ingredient, esomeprazole, although there are differences in indications and directions for use.

The 20mg NEXIUM® capsule will continue to be available by prescription. Other dosages of NEXIUM® will continue to be available by prescription only.

Nexium® 24HR is indicated for adults (18 years and older) with frequent heartburn — when you have heartburn two or more days a week — whereas prescription NEXIUM® is indicated for many acid-related conditions.

To learn more about prescription NEXIUM®, visit

Yes. Both our capsule and new tablet forms have the same formula, with 20 mg of esomeprazole as the active ingredient.

The new yellow cap is an easy-to-open cap that has the Ease of Use recognition from the Arthritis Foundation®. Nexium® 24HR with Easy Open Cap is only available in 28-count.

Nexium® 24HR is the #1 choice of Doctors and Pharmacists for their own frequent heartburn and has been safely prescribed to millions of people over the last 15 years.

How it works

Cells in the lining of the stomach contain proton pumps that produce the acid your body uses during digestion. Heartburn can be caused when this stomach acid flows up into the esophagus. Nexium® 24HR protects you from frequent heartburn by turning your acid pumps from on to off, reducing the amount of acid that rises into your esophagus and alleviating heartburn.

Proton pump inhibitors (PPIs) are a group of medications that stop heartburn at the source by turning off many of the pumps that produce acid. Nexium® 24HR belongs to this group of medications.

Nexium® 24HR may take 1-4 days for full effect, which is 24 hours of complete relief^ from frequent heartburn.
^ It’s possible while taking Nexium® 24HR. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Not for immediate relief.

How to use

People 18 years and older with frequent heartburn (occurring two or more days a week) can take Nexium® 24HR.

Take one Nexium® 24HR capsule with a glass of water before eating each morning for 14 consecutive days.

Do not take more than one capsule each day. You should not chew the capsule or empty its contents into food or drink.

Do not use Nexium® 24HR for longer than 14 days unless your healthcare professional directs you to do so. You can repeat a 14-day regimen once every four months.

Contact your healthcare professional with additional concerns regarding dosage.

You should take Nexium® 24HR once daily, for 14 days. Please use as directed.

Do not take Nexium® 24HR for longer than 14 days unless your healthcare professional directs you to do so. You can repeat a 14-day regimen once every four months.

If you have questions, or concerns, or you continue to experience frequent heartburn, contact your primary healthcare professional.

If you miss or forget to take a dose of Nexium® 24HR, take one as soon as you remember.

However, if you’ve missed a dose and it’s almost time for the next one, do not take the missed dose.

Do not take a double dose to make up for a missed one.

If you have additional questions about dosage, contact your healthcare professional.

You should ask your physician or pharmacist before using Nexium® 24HR while taking other medications.

You should not change or stop taking any prescriptions without first consulting with your healthcare professional. As always, it is important to discuss your frequent heartburn symptoms, lifestyle modifications (diet and exercise) and any acid-related conditions with your healthcare professional. Your healthcare professional may help determine if Nexium® 24HR is the right option to treat your frequent heartburn.

How to buy

On May 27, 2014, Nexium® 24HR became available without a prescription for the treatment of frequent heartburn in stores nationwide and through online retailers.

Insurance coverage for over-the-counter medications may vary and will depend on your specific plan. Check with your insurance provider to find out if over-the-counter medications like Nexium® 24HR are covered on your plan.

Nexium® 24HR is available in drug, grocery, mass merchandiser and club stores nationwide as well as online through online retailers.

Yes. All prescription NEXIUM® indications and formulations remain available with a prescription. However, Nexium® 24HR is available without a prescription for the treatment of frequent heartburn.